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Cholesterol trialist collaboration

WebApr 11, 2015 · We undertook a meta-analysis of statin trials in the Cholesterol Treatment Trialists' (CTT) Collaboration database to compare the effects of statin therapy between women and men. Interpretation: In men and women at an equivalent risk of cardiovascular disease, statin therapy is of similar effectiveness for the prevention of major vascular … WebApr 13, 2024 · Specifically, we calibrated the rate ratio (RR) for ASCVD events associated with a 39 mg/dL reduction in LDL-C from a meta-analysis by the Cholesterol Treatment …

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WebFeb 4, 2024 · In the 28 trials of 186,854 participants, 8% (14,483) were >75 years at baseline and median follow-up was 4.9 years. There was a 21% proportional reduction in major CVEs per 1.0 mmol/L reduction in LDL-C, which decreased insignificantly with age and significantly in all age groups. Overall, statin or more intensive statin therapy yielded … WebBaigent C, Blackwell L, Emberson J, et al; Cholesterol Treatment Trialists’ (CTT) Collaboration. Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials. Lancet. 2010;376(9753):1670-1681.PubMed Google Scholar Crossref running iowa https://keonna.net

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WebThe secretariat of the Cholesterol Treatment Trialists' Collaboration was established to coordinate the prospective meta-analysis. Individual patient data (IPD) were checked for internal consistency and completeness of … Weba concern in the medical community. In the Cholesterol Trialist Collaboration, lowering LDL cholesterol by 2 mmol/L (78 mg/dL) in 10000 patients with previous symptomatic vascular disease would prevent 1000 major vascular events and cause 5 to 10 ICH.3 Trials in sec-ondary prevention of stroke showed a 1.7-fold relative WebJun 1, 1995 · Cholesterol Treatment Trialists' (CTT) Collaboration The Cholesterol Treatment Trialists' Collaboration aims to provide reliable information about the effects on mortality and morbidity of treatments that modify blood lipid levels for a wide range of patient populations and risk groups. sccc parking permit

CAD Severity on Cardiac CTA Identifies Patients With Most Benefit …

Category:CTT: Cholesterol Treatment Trialists

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Cholesterol trialist collaboration

Recurrent Atherosclerotic Cardiovascular Disease Events …

WebAug 11, 2012 · Background: Statins reduce LDL cholesterol and prevent vascular events, but their net effects in people at low risk of vascular events remain uncertain. Methods: This meta-analysis included individual participant data from 22 trials of statin versus control (n=134,537; mean LDL cholesterol difference 1·08 mmol/L; median follow-up 4·8 years) … WebMar 17, 2024 · The orange line represents the 21% major vascular events risk reduction per 1 mmol L −1 (39 mg dL −1) reduction in LDL cholesterol for individuals with baseline coronary heart disease found in statin trials in the Cholesterol Treatment Trialist’ Collaboration meta-analysis. The blue line represents estimated lipoprotein(a) total …

Cholesterol trialist collaboration

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WebSep 27, 2005 · This report is of the results from the first cycle of such meta-analyses, and involves only trials of statins. Methods Study eligibility A protocol for the Cholesterol Treatment Trialists' (CTT) Collaboration … WebMore recent trials have helped to address important additional questions, such as whether more intensive lowering of cholesterol is beneficial and whether the benefits extend to different patient populations. CTSU’s …

WebMar 15, 2015 · Long-term results: Total exposure over the course of the trial was 4.951 patient-years (after year 1, control group patient could cross-over). A total of 1,151 … WebNov 10, 2024 · For these calculations, we assumed 30% and 22% relative risk reduction of myocardial infarction and atherosclerotic cardiovascular disease, respectively, per 1·0 mmol/L reduction in LDL cholesterol in individuals free of atherosclerotic cardiovascular disease, as observed in the Cholesterol Trialist Collaboration meta-analyses.

WebApr 10, 2024 · ‘We included 21 statin trials in our analysis. We appraised the quality of these studies and found them to be largely at low risk of bias. We conducted a meta-analysis on 19 of the 21 trials that reported data on all-cause … WebNov 13, 2010 · We aimed to assess the safety and efficacy of more intensive lowering of LDL cholesterol with statin therapy. Methods: We undertook meta-analyses of …

WebSep 8, 2024 · ‘The company (Novartis) used the Cholesterol Treatment Trialist Collaboration (CTT)meta-analyses, which reported change in cardiovascular event risk per1 mmol/l reduction in LDL-C by statin use. The ERG agreed that these analyses were appropriate and noted that earlier versions of this source were used in past NICE …

WebNov 27, 2024 · Elevated LDL cholesterol and increased risk of myocardial infarction and atherosclerotic cardiovascular disease in individuals aged 70–100 years: a contemporary primary prevention cohort ... as observed in the Cholesterol Trialist Collaboration meta-analyses. 18 Moderate-intensity statin therapy was expected to reduce LDL cholesterol … running in your fiftiesWebOur most recent large randomised trial, REVEAL , tested whether there were additional benefits of treating patients with vascular disease who are already receiving statins with anacetrapib, a new class (CETP inhibitors) … sccc philosophy coursesWebThe Cholesterol Treatment Trialists’ (CTT) Collaboration conducts meta-analyses of cholesterol intervention trials. It was originally established in 1994 with the aim of … scc cows