Ctx-injured muscles
WebNov 1, 2015 · However, CTX injection induced greater muscle degeneration than glycerol injection; vacuolated myofibers could be seen after CTX injection. Small regenerating … WebSep 18, 2024 · e Myofiber minimal Feret’s diameter of CTX-injured and contralateral (ctr) TA muscles from Pax7 CE/+:Mll1 fl/fl mice treated or not with tamoxifen at 21 days post-injury, represented as mean ± ...
Ctx-injured muscles
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WebNov 8, 2016 · TA muscles of recipient BMT animals were injected with CTX 12 weeks after BMT and histological analysis of muscle regeneration was carried out 22 days post injury. When compared with animals that received WT bone marrow (WT BMT), mice that received bone marrow deficient in PPARγ ( Pparg fl/− , Sox2-cre + BMT) exhibited a profound … WebJul 8, 2024 · Quiescent satellite cells were obtained from uninjured hindlimb muscles, while activated satellite cells were obtained from CTX-injured tibialis anterior and gastrocnemius muscles 3 days after the ...
WebApr 11, 2013 · CTX-injured muscles were digested on various days and mononuclear cells were isolated for flow cytometric analysis. Note that all GFP+ cells are of hematopoietic origin (CD45 + ). (C) Expression of various chemokines and cytokines that have been implicated in the recruitment of eosinophils and macrophages in regenerating muscle, n … WebDec 8, 2024 · Therefore, we also checked muscle regeneration after acute muscle injury induced by CTX injection, a method that allows studying muscle regeneration in more controlled and reproducible conditions . In the model of CTX-induced muscle injury, no effect of the lack of Nrf2 transcriptional deficiency was observed.
WebNov 3, 2015 · The number of muscle fibres expressing eMyHC is presented in Figure 2B 2 B and C as their percentage in a total number of muscle fibres in the field of view (six muscles, 10 fields of view per muscle). Analysis of ctx injured wt muscles revealed low number of eMyHC positive fibres that decreased as a consequence of Sdf‐1 treatment. WebMar 24, 2014 · C-telopeptide fragments of type II collagen (CTX-II) are created during articular cartilage breakdown and CTX-II is considered useful as a biomarker of …
WebMar 18, 2024 · b, Maximum isometric tetanic force of CTX-injured TA muscles in adult, aged and mdx mice after transplantation of dermal …
As mentioned above, CTX-induced muscle injury is characterized by the influx of calcium, which might have contributed to the upregulation of the Akt-mTOR axis. In the present study, the expression of the upstream mTORC1 intermediates, e.g. p-Akt and p-mTOR, peaked 5 days following CTX injury compared to … See more We demonstrated that the slower type IIa fibers were more vulnerable to CTX-injection and that the formation of primarily fast muscle fibers preceded the slow fibers in the TA, i.e. slow type IIa fibers were decreased at d2 and … See more Our data reveal that CTX severely impacts muscle histology and molecular signaling. To better understand the regeneration process, the potential physiological meaning(s) of the … See more In their response upon injury, molecular targets exhibit differential expression patterns, reflecting their unique functioning during the … See more Besides the upregulation of a muscle stress response, muscle regeneration is also characterized by an anabolic response (Ge et al. 2009). mTORC1 signaling, which is the key regulator of protein synthesis, … See more phillip and raeWebDec 1, 2016 · Injured muscles were subjected to both histological and ultrastructural analyses. CTX-induced injury caused mitochondrial accumulation and swelling followed by lysis, while glycerol-induced injury caused accumulation of vesicles with focal disruption of the basal lamina, indicating that the injuries have different mechanisms of damage to … phillip and patricia frost art museumWebNov 8, 2016 · Skeletal muscle tissue has an enormous regenerative capacity that is instrumental for a successful defense against muscle injury and wasting. The peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) exerts therapeutic effects in several muscle pathologies, but its role in damage-induced muscle regeneration is unclear. … phillip and patricia museum