Dynein intermediate chain binding

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August undefined, 2024

WebJun 12, 2007 · Here, we present the structure and a thermodynamic analysis of a complex of LC8 and TcTex1 associated with their intermediate chain scaffold. The intermediate … WebMay 15, 2024 · The remarkable ability of dynein to interact with a diverse cargo spectrum stems from its tightly regulated recruitment of cargo-specific adaptor proteins, which …

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WebCentral to the function of this motor protein complex is dynein intermediate chain (IC), which binds the three dimeric dynein light chains at … WebCytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein … how to say fjord horse

Recombinant Anti-Cytoplasmic Dynein Intermediate …

WebAs PDF files, the 1:7500 scale beginner course is here, and the 1:10000 scale intermediate course is here. Directions: From I-695 (Baltimore Beltway), take Exit 13, Frederick Road … WebJan 4, 2005 · Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. Web13411 Ensembl ENSG00000105877 ENSMUSG00000018581 UniProt Q96DT5 n/a RefSeq (mRNA) NM_001277115 NM_010060 RefSeq (protein) NP_001264044 n/a Location (UCSC) Chr 7: 21.54 – 21.9 Mb Chr 12: 117.84 – 118.16 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Dynein axonemal heavy chain 11 (DNAH11), is a … north georgia mountains hotels

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A conserved interaction of the dynein light intermediate …

WebLC4/Ca+2 binding: Related protein: ... Indeed, a direct interaction has been shown between dynein intermediate chain and KLCs. The interaction of these proteins may reflect a … WebFeb 5, 2024 · Predicted to enable dynein intermediate chain binding activity and dynein light intermediate chain binding activity. Predicted to be involved in cilium assembly. Located in 9+0 non-motile cilium and centrosome. Is active in glutamatergic synapse and postsynapse. [provided by Alliance of Genome Resources, Apr 2024] north georgia mountains camping sitesWebCytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and ... north georgia mountains cabin

"WebOct 1, 2014 · The LIC domain structure has interesting parallels with the dynein intermediate chain, which has a well-ordered WD repeat domain that interacts with the heavy chain and a less conserved disordered … " - Dynein intermediate chain binding

Dynein intermediate chain binding

Recruitment of dynein and kinesin to viral particles - Tati - 2024 ...

WebAuthor(s): Rahman, Farhana; Johnson, Jennifer L; Zhang, Jinzhong; He, Jing; Pestonjamasp, Kersi; Cherqui, Stephanie; Catz, Sergio D Abstract: The dynein motor protein complex is required for retrograde transport but the functions of the intermediate-light chains that form the cargo-binding complex are not elucidated and the importance … WebFeb 26, 2007 · The largest subunit of dynactin, p150(glued), binds the dynein intermediate chain and has an N-terminal microtubule-binding domain. To examine the role of microtubule binding by p150(glued), we replaced the wild-type p150(glued) in Drosophila melanogaster S2 cells with mutant DeltaN-p150 lacking residues 1-200, which is unable …

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WebDynein Axonemal Light Chain 4 (DNAL4) protein is understood to be part of the axonemal (or ciliary and flagellar) complex of dynein molecules (including dynein heavy and light chains) (GO:0005858) and a component of the microtubule-based dynein motor complex [13].In humans, two known axonemal light chain proteins, DNAL1 and DNAL4, sit at the … WebJul 13, 2001 · Previously, we identified dynactin as a cargo receptor or adaptor for cytoplasmic dynein, mediated by an interaction between the dynein intermediate chain …

WebFeb 5, 2008 · dynein light intermediate chain binding Source:GO_Central. 1 publication. Molecular Function: minus-end-directed microtubule motor activity Source:GO_Central. 1 publication. ... Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. ... WebMay 1, 2001 · The translocation of dynein along microtubules is the basis for a variety of essential cellular movements. Despite a general domain organization that is found in all the cytoskeletal motors, there are structural features of dynein that set it apart from the other motors. These include a track-binding site that is located at the tip of a long projection, …

WebWe show that human dynein light intermediate chain (DLIC) binds the N-terminal RH1 domain of JIP3, its paralog JIP4, and the lysosomal adaptor RILP. A point mutation in RH1 abrogates DLIC binding without perturbing the interaction between JIP3’s RH1 domain and kinesin heavy chain. WebSep 7, 2024 · The Hook3 HBS1 region was predicted by running Colabfold 1.2.0 (no templates) on two copies of Hook3 172–287 , one copy of dynein heavy chain 576–864 …

WebAlready active dynein does not need ADP-binding (Hayashi and Shingyoji, 2008). Some ODA mutants of Chlamydomonas decrease beating under viscous condition ... Dynein is …

WebApr 7, 2006 · Cytoplasmic dynein is the multisubunit protein complex responsible for many microtubule-based intracellular movements. Its cargo binding domain consists of dimers of five subunits: the intermediate chains, the light intermediate chains, and the Tctex1, Roadblock, and LC8 light chains. The intermediate chains have a key role in the … how to say fizzarolliWebDec 8, 2024 · Dynein_heavy; Dynein heavy chain and region D6 of dynein motor pfam08393 Location: 763 → 1162 DHC_N2; Dynein heavy chain, N-terminal region 2 pfam12777 Location: 2586 → 2933 MT; Microtubule-binding stalk of dynein motor pfam12781 Location: 2962 → 3178 AAA_9; ATP-binding dynein motor region D5 … how to say flashing in spanishWebdata:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAKAAAAB4CAYAAAB1ovlvAAAAAXNSR0IArs4c6QAAAw5JREFUeF7t181pWwEUhNFnF+MK1IjXrsJtWVu7HbsNa6VAICGb/EwYPCCOtrrci8774KG76 ... how to say fix spanishWebMar 7, 2024 · Dynein is a 1.4 MDa homodimeric complex of two heavy chains, which each binds smaller subunits, including the intermediate … how to say flare up in spanishWebJun 1, 2002 · dynein intermediate chain binding Source:GO_Central. 1 publication. Molecular Function: dynein light intermediate chain binding Source:GO_Central. 1 publication. ... Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. ... how to say flahertyWebCytoplasmic dynein is a minus-end-directed microtubule motor important for mitosis, retrograde vesicle transport, and organelle distribution [1–3]. It is a multi-protein complex, and the dynein heavy chain (HC) within the complex is an ATPase responsible for ATP-dependent motility along microtubules [4,5]. how to say flame in different languagesWebHomodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. how to say flabbergasted in spanish