Ion-682884-cs3
WebThe EU Clinical Trials Register currently displays 43188 clinical trials with a EudraCT protocol, of which 7144 are clinical trials conducted with subjects less than 18 years old. The register also displays information on 18700 older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006). WebEplontersen (ION-682884), a ligand-conjugated antisense oligonucleotide designed to degrade hepatic TTR mRNA, is being evaluated for the treatment of ATTRv amyloidosis with polyneuropathy...
Ion-682884-cs3
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Web29 jun. 2016 · IONIS-TTRRx (ISIS 420915) is a 2nd-Generation 2′-O- (2-methoxyethyl) modified “2′-MOE” antisense oligonucleotide (ASO) that targets the TTR RNA transcript and reduces the levels of the TTR transcript through an RNaseH1 mechanism of action, leading to… View on Taylor & Francis ncbi.nlm.nih.gov Save to Library Create Alert Cite 99 … WebCS3 – Phase 3 study in patient with PN Research type Research Study Full title A Phase 3 Global, Open-Label, Randomized Study to Evaluate the Efficacy and Safety of ION …
Web1 feb. 2024 · Design and Rationale of the Global Phase 3 NEURO-TTRansform Study of Antisense Oligonucleotide AKCEA-TTR-LRx (ION-682884-CS3) in Hereditary Transthyretin-Mediated Amyloid Polyneuropathy. WebInclusion Criteria: Satisfactory completion of ION-682884-CS3 (NCT04136184) (Index Study) as judged by the Investigator and Sponsor, or diagnosis of hATTR-PN and satisfactory completion of either study ISIS 420915-CS101 or study 2024-P001436 (NCT03702829) (both are Investigator-Sponsored studies with inotersen – the …
Web21 jun. 2024 · Coelho T, et al. Design and Rationale of the Global Phase 3 NEURO-TTRansform Study of Antisense Oligonucleotide AKCEA-TTR-LRx(ION-682884-CS3) in Hereditary Transthyretin-Mediated Amyloid Polyneuropathy. Neurol Ther. 2024 Jun;10(1):375-389. Web16 dec. 2024 · Introduction Hereditary transthyretin (ATTRv) amyloidosis is a rare, severe, progressive, debilitating, and ultimately fatal disease caused by systemic deposition of transthyretin (TTR) amyloid fibrils. ATTRv amyloidosis occurs in both males and females. Eplontersen (ION-682884), a ligand-conjugated antisense oligonucleotide designed to …
Web28 feb. 2024 · 5. Coelho T, Ando Y, Benson MD, Berk JL, Waddington-Cruz M, Dyck PJ, et al. Design and rationale of the global phase 3 NEURO-TTRansform Study of Antisense Oligonucleotide AKCEA-TTR-L Rx (ION-682884-CS3) in hereditary transthyretin-mediated amyloid polyneuropathy. Neurol Ther. (2024) 10:375–89. doi: 10.1007/s40120-021-00235-6
Web13 nov. 2024 · ION-682884-CS2 (EudraCT No: 2024-002835-27) is a Phase 3 global, double-blind, randomized, placebo-controlled study assessing the efficacy and safety of AKCEA-TTR-L Rx (ION-682884) in hATTR-CM or wtATTR-CM patients receiving available background standard of care (SoC) therapy. porta hootyWeb13 nov. 2024 · ION-682884-CS2 (EudraCT No: 2024-002835-27) is a Phase 3 global, double-blind, randomized, placebo-controlled study assessing the efficacy and safety of … porta hooty reporting for hootyporta hepatis mass icd 10Web23 okt. 2024 · Coelho T, Ando Y, Benson MD, Berk JL, Waddington-Cruz M, Dyck PJ, Gillmore JD, Khella SL, Litchy WJ, Obici L, Monteiro C, Tai LJ, Viney NJ, Buchele G, Brambatti M, Jung SW, St L O'Dea L, Tsimikas S, Schneider E, Geary RS, Monia BP, Gertz M. Design and Rationale of the Global Phase 3 NEURO-TTRansform Study of Antisense … ironwood golf course grandville miWeb10 mrt. 2024 · A Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single-Ascending and Multiple Doses of Eplontersen (Formerly … ironwood golf course fishers inWeb26 feb. 2024 · AKCEA-TTR-L Rx (ION-682884) is a ligand-conjugated antisense (LICA) drug designed for preferential delivery to hepatocytes, the primary source of systemically … ironwood golf course jobsWebEplontersen (ION-682884), a ligand-conjugated antisense oligonucleotide designed to degrade hepatic TTR mRNA, is being evaluated for the treatment of ATTRv amyloidosis … ironwood golf course gainesville florida