WebExamples of drugs that follow zero-order kinetics at high concentrations are: ethanol, phenytoin, salicylates. Capacity-limited or nonlinear kinetics occurs when the rate of elimination shifts from first-order to zero-order, based on saturation of elimination processes. Essentially any drug can become capacity-limited in an overdose situation.
PNYG - Overview: Phenytoin, Total and Phenobarbital Group, Serum
WebInitial therapy with phenytoin is started at doses of 100 to 300 mg/day for adults or 4 mg/kg/day for children. Because absorption is variable and the drug exhibits zero-order (nonlinear) kinetics, dose must be adjusted within 5 days using blood concentration to guide therapy. Oral bioavailability ranges from 80% to 95% and is diet-dependent. Webin phenytoin pharmacokinetics and/or efficacy and toxicity. Furthermore, phenytoin demonstrates non-linear pharmacokinetics even within the therapeutic range. The enzyme system involved in phenytoin metabolism gradually becomes saturated, resulting in a … how to screen mirror to fire stick
Nonlinear Pharmacokinetics Flashcards Quizlet
WebPhenytoin is a relatively insoluble weak acid, usually administered as the sodium salt. Bioavailability is dependent upon particle size and problems of generic inequivalence have … WebPhenytoin metabolism is nonlinear elimination kinetics shift from first-order to zero-order at moderate to high dose levels. The drug binds extensively to plasma proteins (97-98%), and free (unbound) phenytoin levels in plasma are increased transiently by drugs that compete for binding (eg, sulfonamides, valproic acid ). WebNational Center for Biotechnology Information how to screen mirror to roku